CIB1 as a Potential Diagnosis and Prognosis Biomarker in Uveal Melanoma

Background: Uveal melanoma (UVM) is the most common primary intraocular tumor in adults. However, identification of effective biomarker for diagnosis and treatment UVM remains to be explored. Calcium integrin-binding protein 1 (CIB1) emerging as an important factor progression. Purpose: To determine contribution CIB1 UVM. Method: Immunohistochemical staining used detect expression level, while Gene Expression Profiling Interactive Analysis 2 (GEPIA2) UALCAN online tools were analyze patient survival correlation genes Integrative analysis using STRING GeneMANIA predicted correlated with Results: level was significantly enhanced when compared that paracancerous tissues. A higher resulted a worse disease-free well overall survival. Moreover, probability patients associated body weight gender The UVM, similarity heatmap verified. Furthermore, ontology enrichment revealed its are enriched ITGA2B-ITGB3-CIB1 complex, regulation intracellular transport ion transport. Conclusions: Our novel findings suggested might potential diagnostic predictor contribute strategy by targeting